Reservoirs properties of slump-type sub-lacustrine fans and their main control factors in first member of Paleogene Shahejie Formation in Binhai area, Bohai Bay Basin, China

High-yielding oil wells were recently found in the first member of Paleogene Shahejie Formation, the Binhai area of Qikou Sag, providing an example of medium- and deep-buried high-quality reservoirs in the central part of a faulted Cooler Bag lacustrine basin.By using data of cores, cast thin sections, scanning electron microscope and physical prop

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Discovering covalent cyclic peptide inhibitors of peptidyl arginine deiminase 4 (PADI4) using mRNA-display with a genetically encoded electrophilic warhead

Abstract Covalent drugs can achieve high potency with long dosing intervals.However, concerns remain about side-effects associated with off-target Dairy Rescue reactivity.Combining macrocyclic peptides with covalent warheads provides a solution to minimise off-target reactivity: the peptide enables highly specific target binding, positioning a weak

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